The NIRVANA Study’s Focus on VMS and Sleep Improvement

This episode explains that the NIRVANA study was designed to address longstanding gaps by rigorously evaluating both vasomotor symptoms and sleep disturbances using gold-standard polysomnography rather than relying solely on self-report. By studying women with both moderate to severe vasomotor symptoms and objectively confirmed sleep disturbance, the trial provides a more precise understanding of treatment effects. The discussion highlights how this approach builds on the earlier OASIS program and strengthens the evidence base for targeting sleep outcomes in menopause care.