6 Best GLP-1 Programs for Postpartum Weight Loss, Expert-Approved

If you purchase an independently reviewed product or service through a link on our website, SheKnows may receive an affiliate commission.

Postpartum weight loss isn’t always about giving in to “bounce back” culture. Instead, it’s helping mothers align their health and fitness goals after a monumental life event, and feel like themselves again, whether it’s about the number on the scale or lowering visceral fat, which helps reduce diseases like cardiovascular disease and type 2 diabetes. That’s where the best GLP-1 programs come in. The medications are revitalizing postpartum health, and an increasing number of women are seeking them out. But with so many options available, it can be overwhelming to decide on a program that’s best for you.

The best programs are those that take a personalized, medically supervised approach. “Postpartum weight loss isn’t just about the number on the scale: It’s about hormonal health, metabolic changes, and long-term wellbeing,” explains Dr. Melynda Barnes, Chief Medical Officer at Ro. “Programs that combine clinical oversight with nutrition, lifestyle support, and ongoing monitoring tend to be the most effective, as they meet women where they are rather than applying a one-size-fits-all solution.”

Keep reading to learn more about the medications and the best programs to help you reach your postpartum goals.

Best GLP-1 Programs for Postpartum Weight Loss, at a Glance

Best Overall: Noom, $129
Best Runner-Up: Ro, $199+
Most Popular Program: Mochi, $79+
Most Affordable Program: Ivim Health, $75+
Best Specialized Women’s Program: Hers, $149+
Best App-Based Program: Fridays, $150+

How do GLP-1 Medications Work?

GLP-1 medications work by suppressing appetite and increasing weight loss. There are also many other functions the medications serve, like addressing some of the underlying biological drivers of weight gain, according to Dr. Melynda Barnes, Chief Medical Officer at Ro. “They help regulate appetite and metabolism by slowing gastric emptying, increasing feelings of fullness, and reducing cravings,” she adds. “They also improve insulin sensitivity, which plays a key role in how the body stores and uses energy. This makes them particularly effective during life stages like postpartum or aging, when hormonal shifts can disrupt normal metabolic function.”

Here’s how it works on a more scientific level: GLP-1 is a hormone your body already makes. It helps regulate blood sugar, slows the rate at which food moves through your stomach, and signals fullness to your brain. “GLP-1 medications like semaglutide mimic that hormone, which is why people feel satisfied with less food and notice the constant chatter about food, what we call ‘food noise,’ quiet down,” explains Dr. Jessica Duncan, an obesity certified MD and Chief Medical Officer at Ivim Health. “They’re not appetite suppressants in the old sense. They’re working on the biological drivers of hunger and metabolism.”

 Can You Take GLP-1s Postpartum?

GLP-1s are generally safe to take postpartum, but there are caveats according to experts. Dr. Duncan explains that GLP-1s are not approved or studied during pregnancy or breastfeeding, so the postpartum window is really about timing. “Once a patient is no longer breastfeeding and their body has had time to recover from delivery, GLP-1 therapy can be appropriate, and for many women dealing with significant postpartum weight concerns, hormonal shifts, and metabolic changes, it can be life-changing,” she says. And since every case is different, it’s best to be evaluated by your provider first.

Dr. Amy B. Lewis, a Yale-trained board-certified dermatologist in private practice in New York City, also adds that the safety of using a GLP-1 should be determined based on nutritional status, including iron stores, protein stores, hormone recovery, and breastfeeding status.

How Soon Can You Take a GLP-1 After Giving Birth? 

Much like returning to physical activity postpartum, it’s best to give your body time to rest and heal after giving birth. “There’s no single number that applies to everyone, and I’d be skeptical of any program that gives you one,” Dr. Duncan says. “What I think about with my patients: Are you finished breastfeeding? Has your body stabilized, meaning hormones, cycle, and sleep are settling into a new rhythm? Are you medically cleared by your OB?”

Experts say that this time period is past the six-week postpartum visit, and sometimes longer when breastfeeding.

Is Taking GLP-1s Safe While Breastfeeding?

GLP-1s are not recommended for those who are breastfeeding. The side effects haven’t been studied enough to know if the medication is transferred into breastmilk and then to an infant. Doctors are concerned with the potential harmful effects on an infant’s growth and feeding if GLP-1s get into the bloodstream. “In addition, appetite suppression in the mother may reduce caloric intake needed for milk production,” Dr. Lewis says.

Are GLP-1s, Constipation & Your Pelvic Floor Related? 

Every expert agrees that the most common side effects of GLP-1s are constipation. “In our published research on more than a thousand patients on tirzepatide, constipation was the single most reported side effect,” Dr. Duncan notes. “Now layer that on a postpartum body, where the pelvic floor is already healing from pregnancy and delivery, and yes, there can be a real connection.” Putting additional strain from constipation adds even more stress and pressure onto the pelvic floor that’s already trying to heal.

“The fix isn’t to avoid GLP-1s. It’s to, first, allow the body to heal post-partum and, second, manage the constipation proactively with hydration, fiber, gentle movement, and consider certain over-the-counter aids or even working with a pelvic floor physical therapist — this is exactly the kind of nuance that gets missed when someone’s just handed a prescription with no support,” Dr. Duncan explains.

Are the Side Effects of a GLP-1 Heightened During Postpartum? 

In addition to constipation, there are a handful of other side effects that a woman can experience when on a GLP-1, such as nausea, fatigue, and decreased appetite. “These are similar to what any patient might experience, but in the postpartum phase, when the body is already adjusting to hormonal shifts and sleep deprivation, they can feel more pronounced,” Dr. Barnes shares.

So yes, these symptoms can be heightened during postpartum. This time is defended by major hormonal fluctuations, increased prolactin, and often significant sleep disruption, which makes the body more sensitive overall.

I was on a GLP-1 before getting pregnant with my second daughter and had a phenomenal experience — minimal side effects, maximum weight loss in under eight months, and improved muscle tone — the entire year I was on it was a breeze. And then I got pregnant. I delivered my daughter in December, and my plan was always to get back on a GLP-1. Now, five months later, I’m no longer breastfeeding and have been back on the same medication. Although I’m looking forward to the results and feeling like myself again, this round is no walk in the park. The side effects are heightened and feel like prolonged morning sickness. I attribute it to my hormones still stabilizing and having to re-adjust to the medication once again.

Another SHE Media member, Gina Vaynshteyn (AVP, Commerce), also started a GLP-1 program postpartum. “I started a micro-dose program with Hers a little over a year postpartum. I was done breastfeeding and really hit a wall with my weight, but was also having issues with energy and inflammation. I decided (with the support of my healthcare provider) to try a microdose GLP-1 program, which was really great for me. From November 2025 to now (May 2026), I’m back to my pre-pregnancy weight, I feel more energized, and I’m not constantly dealing with ‘food noise’ that tells me to demolish an entire bag of Doritos in between back-to-back work calls. I can finally fit in my pre-baby clothes again, and I feel confident in my body! The dosing has been so gradual that the side effects have honestly been very minimal. Tldr; as a postpartum mom, I’ve had a great experience with my GLP-1,” she shares.

Ahead, explore the best GLP-1 programs for postpartum weight loss, approved by experts.

The Best GLP-1 Programs for Postpartum Weight Loss

About the Author

Taylor Lane is a contributing commerce writer at SheKnows, covering beauty, style, and lifestyle. With over eight years of media experience, she previously served as a beauty writer at The Zoe Report and a fashion assistant at Glamour. Her work has appeared in StyleCaster, The FlowSpace, WWD, Forbes Vetted, Teen Vogue, InStyle, and more, where she’s tested hundreds of products — from top-performing mascaras to the most functional strollers. She’s also a mom of two girls, a ten-year-old and a 4-month-old. And when she’s not online, she’s usually at Pilates.

Before you go, check out our slideshow below: